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Defeat shock allergies

For many allergy sufferers, allergies are among the worst summer days. For those who have acquired it, sneezing, runny nose, watery eyes and itching, it all starts when the immune system believes that the incoming pollen and mold are threats to the fight - and then overloads.

One of the best ways to fight allergies (in addition to allergy medication) is to give your immune system a head start. Before the allergy season begins (after living in a region for a few years, you'll feel pretty good), try eating more vegetables and fruits and reducing foods that suppress the immune system. Things like chocolate, coffee, sugar, and dairy products contribute to overloading your immune system. By reducing, you are helping your immune system to have more juice to fight the coming tide.

Regarding juice, some experts say that quick juice is another great way to prepare your body for the allergy season. Start by replacing one meal with juice, then two, then three, and then continue up to three meals a day in the other direction. By drinking organic juices instead of eating for a few days, you can help your body get rid of the toxins that your immune system neutralizes daily.

Supplement supplements like vitamin C, nettle, and quercetin, and you can fight many allergens that are starting to attack.

The simplest defense is avoidance. Use the air conditioner instead of opening the windows, and stay indoors when it is dry and windy outside, because it is where most of the allergens are thrown into the air. Keep your house clean and eliminate as many allergens as possible by washing things with hot water and cleaning them regularly. So you can survive the allergy season.

Medicines for allergic rhinitis

Fexofenadine is a new non-sedative antihistamine. It is the active metabolite of terfenadine that has been withdrawn from the market in some countries. Fexofenadine is a safer alternative with similar efficacy to relieve symptoms associated with seasonal allergic rhinitis or hives.

Context

Seasonal allergic rhinitis or hay fever have a significant impact on a patient's quality of life, especially if his sleep is disturbed. Serious symptoms can lead to loss of time at work or school or reduced daily activities. A careful medical history is the most important part of the clinical evaluation. If the symptoms are seasonal, an allergy to pollen is more likely, while perennial symptoms indicate an allergy to mites, mold, or pets. Antihistamines (H1 receptor antagonists) relieve symptoms (e.g. runny nose, sneezing, itching / watery eyes). However, they are ineffective in relieving nasal congestion, although intranasal corticosteroids are effective in this regard.

The new anthistamines terfenadine, loratadine and astemizole have been developed to reduce the side effects of drowsiness and dry mouth with older anthistamines. Therefore, these new anthistamines are preferred when these side effects pose a significant problem (ie when vigilance and motor coordination are required). When medication is widely used in the clinic, rare but serious adverse events are sometimes noted. Terfenadine has been withdrawn from the market in some countries due to serious and sometimes fatal cardiac arrhythmias (e.g. torsions de pointes). These were due to high plasma levels due to concomitant use of ketoconazale and erythromycin or, in some patients, to liver disease. Terfenadine is also contraindicated with other medicines such as HIV protease inhibitors, serotonin reuptake inhibitors, cileutin, cisapride and sparfloxacin. Similar contraindications are observed with astemizole.

Fexofenadine is the active acid metabolite. Because fexofenadine does not require metabolic transformation, rare cardiac side effects and other drug interactions should be minimized. Fexofenadine is indicated for the symptomatic relief of seasonal allergic rhinitis and hives in adults and children over 12 years of age. If antihistamines are to be taken, they should be used regularly and not sporadically.

Clinical outcomes

In placebo-controlled studies in large groups of patients (n = 545 and n = 861) with allergic rhinitis, the efficacy of fexofenadine, which was administered in doses of 60 mg twice daily and once daily, 120 or 180 mg day, was demonstrated.

At the meeting of the American Academy of Allergy, Asthma and Immunology, two placebo-controlled studies were presented that showed a significant improvement in symptoms and quality of life. Patients with moderate to severe rhinitis received fexofenadine 60 mg twice daily or fexofenadine 120 or 18 mg once daily.

Compared to cetirizine in a double-blind study, fexofenadine 120 or 180 mg once daily was also effective in controlling the symptoms of rhinitis. The effectiveness of fexofenadine also appears to be comparable to that of loratadine. Two double-blind studies were presented to show that loratadine 10 mg once daily worked faster in 836 patients than fexofenadine 60 mg twice daily and that patients who did not respond to fexofenadine were more likely to respond to loratadine, and that loratadine was less likely to fail ,

Fexofenadine also effectively relieves the symptoms associated with hives. A higher dose of 180 or 240 mg once a day for 6 weeks significantly reduced the overall symptoms (number of papules or hives and itching). At last year's meeting of the American College of Allergy, Asthma and Immunology, three studies were presented that demonstrate the twice daily use of fexofenadine 60 mg in the treatment of patients with chronic idiopathic urticaria.

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